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Publications

A selection of recent  publications from members of the Centre for Antimicrobial Resistance are shown below:

 

Rzewuska, M, Charani, E, Clarkson, J, Davey, P, Duncan, EM, Francis, J, Gillies, K, Kern, WV, Lorencatto, F, Marwick, CA, Mc Ewen, J, Möhler, R, Morris, AM, Ramsay, CR, Rogers Van Katwyk, S, Skodvin, B, Smith, I & Suh, KN & Grimshaw, JM 2018, 'Prioritizing research areas for antibiotic stewardship programmes in hospitals: a behavioural perspective consensus paper'Clinical Microbiology and Infection
https://doi.org/10.1016/j.cmi.2018.08.020


Burton, JK, Marwick, CA, Galloway, J, Hall, C, Nind, T, Reynish, EL & Guthrie, B 2018, 'Identifying care-home residents in routine healthcare datasets: a diagnostic test accuracy study of five methods'Age and Ageing
https://doi.org/10.1093/ageing/afy137

Rennie, TJW, De Souza, N, Donnan, PT, Marwick, CA, Davey, P, Dreischulte, T & Bell, S 2018, 'Risk of Acute Kidney Injury following community prescription of antibiotics: self-controlled case series'Nephrology Dialysis Transplantation
https://doi.org/10.1093/ndt/gfy187

Chalmers, JD, Chang, AB, Chotirmall, SH, Dhar, R & Mc Shane, PJ 2018,  'Bronchiectasis'vol. 4, no. 1, 45. 
https://doi.org/10.1038/s41572-018-0042-3

 

Radovanovic, D, Santus, P, Blasi, F, Sotgiu, G, D'Arcangelo, F, Simonetta, E, Contarini, M, Franceschi, E, Goeminne, PC, Chalmers, JD & Aliberti, S 2018, 'A comprehensive approach to lung function in bronchiectasis' Respiratory Medicine, vol. 145, pp. 120-129. 
https://doi.org/10.1016/j.rmed.2018.10.031


O'Neill, K, Lakshmipathy, GR, Ferguson, K, Cosgrove, D, Hill, AT, Loebinger, M, Carroll, M, Chalmers, J, Gatheral, T, Johnson, C, De Soyza, A, Hurst, JR, Bradbury, I, Elborn, JS & Bradley, JM 2018, 'Quality control for multiple breath washout tests in multicentre bronchiectasis studies: Experiences from the BRONCH-UK clinimetrics study'Respiratory Medicine, vol. 145, pp. 206-211. 
https://doi.org/10.1016/j.rmed.2018.10.030


Terranova, L, Oriano, M, Teri, A, Ruggiero, L, Tafuro, C, Marchisio, P, Gramegna, A, Contarini, M, Franceschi, E, Sottotetti, S, Cariani, L, Bevivino, A, Chalmers, JD, Aliberti, S & Blasi, F 2018, 'How to Process Sputum Samples and Extract Bacterial DNA for Microbiota Analysis'International Journal of Molecular Sciences, vol. 19, no. 10, 3256, pp. 1-12. 
https://doi.org/10.3390/ijms19103256


Chalmers, JD, Djamin, RS, Schouten, M, Keir, HR, Tan, B, Aerts, JGJV, Huang, JT-J & van der Eerden, M 2018, 'Circulating desmosine as a biomarker of azithromycin treatment response: a post hoc analysis of the COLUMBUS randomised controlled trial'ERJ Open Research, vol. 4, no. 4, pp. 1-4. 
https://doi.org/10.1183/23120541.00136-2018


Contarini, M, Finch, S & Chalmers, JD 2018, 'Bronchiectasis: a case-based approach to investigation and management'European Respiratory Review, vol. 27, no. 149, 180016, pp. 1-13. 
https://doi.org/10.1183/16000617.0016-2018


Mac Aogáin, M, Tiew, PY, Lim, AYH, Low, TB, Tan, GL, Hassan, T, Ong, TH, Pang, SL, Lee, ZY, Gwee, XW, Martinus, C, Sio, YY, Matta, SA, Ong, TC, Tiong, YS, Wong, KN, Narayanan, S, Bijin Au, V, Marlier, D, Keir, HR, Tee, A, Abisheganaden, JA, Koh, MS, Wang, DY, Connolly, JE, Chew, FT, Chalmers, JD & Chotirmall, SH 2018,  'Distinct 'Immuno-Allertypes' of Disease and High Frequencies of Sensitisation in Non-Cystic-Fibrosis Bronchiectasis'American Journal of Respiratory and Critical Care Medicine
https://doi.org/10.1164/rccm.201807-1355OC


Suntila, NS, Smith, A, Al-Dabbagh, Y & Chalmers, JD 2018, 'A systematic review of clinical trial registration in major respiratory journals 2010-2018'European Respiratory Journal
https://doi.org/10.1183/13993003.01491-2018

 

Lederer, DJ, Bell, SC, Branson, RD, Chalmers, JD, Marshall, R, Maslove, DM, Ost, DE, Punjabi, NM, Schatz, M, Smyth, AR, Stewart, PW, Suissa, S, Adjei, AA, Akdis, CA, Azoulay, É, Bakker, J, Ballas, ZK, Bardin, PG, Barreiro, E, Bellomo, R, Bernstein, JA, Brusasco, V, Buchman, TG, Chokroverty, S, Collop, NA, Crapo, JD, Fitzgerald, DA, Hale, L, Hart, N, Herth, FJ, Iwashyna, TJ, Jenkins, G, Kolb, M, Marks, GB, Mazzone, P, Moorman, JR, Murphy, TM, Noah, TL, Reynolds, P, Riemann, D, Russell, RE, Sheikh, A, Sotgiu, G, Swenson, ER, Szczesniak, R, Szymusiak, R, Teboul, J-L & Vincent, J-L 2018, 'Control of Confounding and Reporting of Results in Causal Inference Studies: Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals'Annals of the American Thoracic Society
https://doi.org/10.1513/Annals ATS.201808-564PS


 

Flume, PA, Chalmers, JD & Olivier, KN 2018, 'Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity'The Lancet, vol. 392, no. 10150, pp. 880-890. 
https://doi.org/10.1016/S0140-6736(18)31767-7

 

Chalmers, JD & Chotirmall, SH 2018, 'Bronchiectasis: new therapies and new perspectives'The Lancet Respiratory Medicine, vol. 6, no. 9, pp. 715-726. 
https://doi.org/10.1016/S2213-2600(18)30053-5

 

Boaventura, R, Sibila, O, Agusti, A & Chalmers, JD 2018, 'Treatable traits in bronchiectasis'European Respiratory Journal, vol. 52, no. 3, 1801269. 
https://doi.org/10.1183/13993003.01269-2018


 

Restrepo, MI, Babu, BL, Reyes, LF, Chalmers, JD, Soni, NJ, Sibila, O, Faverio, P, Cilloniz, C, Rodriguez-Cintron, W & Aliberti, S 2018, 'Burden and Risk Factors for Community-acquired Pneumonia: a Multinational Point Prevalence Study of Hospitalised Patients'European Respiratory Journal, vol. 52, no. 2, 1701190. 
https://doi.org/10.1183/13993003.01190-2017

 

IRENE Network, Aliberti, S, Codecasa, LR, Gori, A, Sotgiu, G, Spotti, M, Di Biagio, A, Calcagno, A, Nardini, S, Assael, BM, Tortoli, E, Besozzi, G, Ferrarese, M, Matteelli, A, Girardi, E, De Lorenzo, S, Seia, M, Gramegna, A, Del Prato, B, Terranova, L, Oriano, M, Sverzellati, N, Mirsaeidi, M, Chalmers, JD, Haworth, CS, Loebinger, MR, Aksamit, T, Winthrop, K, Ringshausen, FC, Previdi, G & Blasi, F 2018,  'The Italian registry of pulmonary non-tuberculous mycobacteria - IRENE: The study protocol'Multidisciplinary Respiratory Medicine, vol. 13, no. Suppl. 1, 33. 
https://doi.org/10.1186/s40248-018-0141-8


 

Aliberti, S & Chalmers, JD 2018, 'Get together to increase awareness in bronchiectasis: A report of the 2nd World Bronchiectasis Conference'Multidisciplinary Respiratory Medicine, vol. 13, 28. 
https://doi.org/10.1186/s40248-018-0138-3


 

Contarini, M, Shoemark, A, Rademacher, J, Finch, S, Gramegna, A, Gaffuri, M, Roncoroni, L, Seia, M, Ringshausen, FC, Welte, T, Blasi, F, Aliberti, S & Chalmers, JD 2018, 'Why, when and how to investigate primary ciliary dyskinesia in adult patients with bronchiectasis'Multidisciplinary Respiratory Medicine, vol. 13, no. Suppl 1, 26, pp. 29-38. 
https://doi.org/10.1186/s40248-018-0143-6

 

Waterer, G & Chalmers, J 2018, 'The elusive hunt for a reliable biomarker in community-acquired pneumonia are we searching for something that can't exist?'American Journal of Respiratory and Critical Care Medicine, vol. 198, no. 3, pp. 300-302. 
https://doi.org/10.1164/rccm.201803-0462ED

 

Dicker, AJ, Crichton, ML, Cassidy, AJ, Brady, G, Hapca, A, Tavendale, R, Einarsson, GG, Furrie, E, Elborn, JS, Schembri, S, Marshall, SE, Palmer, CNA & Chalmers, JD 2018,  'Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD'Thorax, vol. 2018, no. 73, pp. 510-518. 
https://doi.org/10.1136/thoraxjnl-2016-209931

 

Mc Donnell, MJ, O'Toole, D, Ward, C, Pearson, JP, Lordan, JL, De Soyza, A, Loebinger, M, Chalmers, JD, Laffey, JG & Rutherford, RM 2018, 'A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk'Respiratory Medicine, vol. 141, pp. 132-143. 
https://doi.org/10.1016/j.rmed.2018.06.031

 

Nawrot, TS & Chalmers, J2018, 'The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: A case-crossover analysis'European Respiratory Journal, vol. 52, no. 1, 1702557. 
https://doi.org/10.1183/13993003.02557-2017


 

Mac Aogáin, M, Chandrasekaran, R, Lim Yick Hou, A, Teck Boon, L, Liang Tan, G, Hassan, T, Thun How, O, Hui Qi Ng, A, Bertrand, D, Yu Koh, J, Lei Pang, S, Yang Lee, Z, Wei Gwee, X, Martinus, C, Yie Sio, Y, Anusha Matta, S, Tim Chew, F, Keir, HR, Connolly, JE, Arputhan Abisheganaden, J, Siyue Koh, M, Nagarajan, N, Chalmers, JD & Chotirmall, SH 2018,  'Immunological corollary of the pulmonary mycobiome in bronchiectasis: The Cameb study'European Respiratory Journal
https://doi.org/10.1183/13993003.00766-2018


Donovan, T, Felix, LM, Chalmers, JD, Milan, SJ, Mathioudakis, AG & Spencer, S 2018,  'Continuous versus intermittent antibiotics for bronchiectasis'Cochrane Database of Systematic Reviews, vol. 2018, no. 6, CD012733, pp. 1-30. 
https://doi.org/10.1002/14651858.CD012733.pub2


Chalmers, JD, Aliberti, S, Filonenko, A, Shteinberg, M, Goeminne, PC, Hill, AT, Fardon, TC, Obradovic, D, Gerlinger, C, Sotgiu, G, Operschall, E, Rutherford, RM, Dimakou, K, Polverino, E, De Soyza, A & Mc Donnell, MJ 2018,  'Characterisation of the "Frequent Exacerbator Phenotype" in Bronchiectasis'American Journal of Respiratory and Critical Care Medicine, vol. 197, no. 11, pp. 1410-1420. 
https://doi.org/10.1164/rccm.201711-2202OC


Liu, NM, van Aalderen, W, Carlsen, KCL, Coleman, C, Chalmers, JD, Cunningham, S, Fernandes, RM, Fleming, LJ, Gappa, M, Karadag, B, Midulla, F, Pijnenburg, MWH, Rutjes, NW, Rusconi, F & Grigg, J 2018, 'Severe Paediatric Asthma Collaborative in Europe (SPACE): protocol for a European registry'Breathe, vol. 14, no. 2, pp. 93-98. 
https://doi.org/10.1183/20734735.002018

Dudgeon, EK, Crichton, M & Chalmers, J 2018, '"The missing ingredient": The patient perspective of health related quality of life in bronchiectasis: a qualitative study'BMC Pulmonary Medicine, vol. 18, 81. 
https://doi.org/10.1186/s12890-018-0631-7

 

Chotirmall, SH & Chalmers, JD 2018, 'Bronchiectasis: an emerging global epidemic'BMC Pulmonary Medicine, vol. 18, 76, pp. 1-3. 
https://doi.org/10.1186/s12890-018-0629-1


 

Chandrasekaran, R, Mac Aogáin, M, Chalmers, JD, Elborn, SJ & Chotirmall, SH 2018,  'Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis'BMC Pulmonary Medicine, vol. 18, 83, pp. 1-14. 
https://doi.org/10.1186/s12890-018-0638-0


 

Mendes, MA & Chalmers, JD 2018, 'Predicting outcomes in bronchiectasis'Pulmonology, vol. 24, no. 3, pp. 146-148. 
https://doi.org/10.1016/j.pulmoe.2018.04.004

 

Chalmers, JD, Poole, C, Webster, S, Tebboth, A, Dickinson, S & Gayle, A 2018, 'Assessing the healthcare resource use associated with inappropriate prescribing of inhaled corticosteroids for people with chronic obstructive pulmonary disease (COPD) in GOLD groups A or B: an observational study using the Clinical Practice Research Datalink (CPRD)'Respiratory Research, vol. 19, 63, pp. 1-9. 
https://doi.org/10.1186/s12931-018-0767-2

 

Torres, A, Cillóniz, C, Blasi, F, Chalmers, JD, Gaillat, J, Dartois, N, Schmitt, H-J & Welte, T 2018, 'Burden of pneumococcal community-acquired pneumonia in adults across Europe: A literature review'Respiratory Medicine, vol. 137, pp. 6-13. 
https://doi.org/10.1016/j.rmed.2018.02.007

 

Kelly, C, Chalmers, JD, Crossingham, I, Relph, N, Felix, LM, Evans, DJ, Milan, SJ & Spencer, S 2018, 'Macrolide antibiotics for bronchiectasis'Cochrane Database of Systematic Reviews, vol. 2018, no. 3, CD012406, pp. 1-79. 
https://doi.org/10.1002/14651858.CD012406.pub2

 

Chalmers, JD 2018,  'Bronchiectasis Exacerbations Are Heart-Breaking'Annals of the American Thoracic Society, vol. 15, no. 3, pp. 301-303. 
https://doi.org/10.1513/Annals ATS.201710-832ED


 

Chalmers, JD, Aksamit, T, Carvalho, ACC, Rendon, A & Franco, I 2018, 'Non-tuberculous mycobacterial pulmonary infections'Pulmonology, vol. 24, no. 2, pp. 120-131. 
https://doi.org/10.1016/j.pulmoe.2017.12.005

 

Suarez-Cuartin, G, Giner, J, Merino, JL, Rodrigo-Troyano, A, Feliu, A, Perea, L, Sanchez-Reus, F, Castillo, D, Plaza, V, Chalmers, JD & Sibila, O 2018, 'Identification of Pseudomonas aeruginosa and airway bacterial colonization by an electronic nose in bronchiectasis'Respiratory Medicine, vol. 136, pp. 111-117. 
https://doi.org/10.1016/j.rmed.2018.02.008

 

 

Chalmers, JD 2018, 'POINT: Should an Attempt Be Made to Withdraw Inhaled Corticosteroids in All Patients With Stable GOLD 3 (30% ≤ FEV <50% Predicted) COPD? Yes'CHEST
https://doi.org/10.1016/j.chest.2018.01.029

 

Araújo, D, Shteinberg, M, Aliberti, S, Goeminne, PC, Hill, AT, Fardon, TC, Obradovic, D, Stone, G, Trautmann, M, Davis, A, Dimakou, K, Polverino, E, De Soyza, A, Mc Donnell, MJ & Chalmers, JD 2018, 'The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis'European Respiratory Journal
https://doi.org/10.1183/13993003.01953-2017

 

Chalmers, JD, Ringshausen, FC, Harris, B, Elborn, JS, Posthumus, A, Haworth, CS, Pilkington, N, Polverino, E, Ruddy, T, Aliberti, S, Goeminne, PC, Winstanley, C & De Soyza, A 2018, 'Cross-infection risk in patients with bronchiectasis: a position statement from the European Bronchiectasis Network (EMBARC), EMBARC/ELF patient advisory group and European Reference Network (ERN-Lung) Bronchiectasis Network'European Respiratory Journal, vol. 51, no. 1, 1701937. 
https://doi.org/10.1183/13993003.01937-2017


 

Chalmers, JD, Polverino, E & on behalf of the European Respiratory Society Bronchiectasis Guidelines Task Force 2018, 'Macrolides, mucoactive drugs and adherence for the management of bronchiectasis'European Respiratory Journal, vol. 51, no. 1, 1702033. 
https://doi.org/10.1183/13993003.02033-2017


 

Dicker, AJ, Crichton, ML, Pumphrey, EG, Cassidy, AJ, Suarez-Cuartin, G, Sibila, O, Furrie, E, Fong, CJ, Ibrahim, W, Brady, G, Einarsson, GG, Elborn, JS, Schembri, S, Marshall, SE, Palmer, CNA & Chalmers, JD 2018, 'Neutrophil Extracellular Traps are associated with disease severity and microbiota diversity in Chronic Obstructive Pulmonary Disease'Journal of Allergy and Clinical Immunology, vol. 141, no. 1, pp. 117-127. 
https://doi.org/10.1016/j.jaci.2017.04.022


 

Chotirmall, SH & Chalmers, JD 2018, 'RESPIRE: breathing new life into bronchiectasis'European Respiratory Journal, vol. 51, no. 1, 1702444. 
https://doi.org/10.1183/13993003.02444-2017

Barini E, Miccoli A, Tinarelli F, Mulholland K, Kadri H, Khanim F, Stojanovski L, Read KD, Burness K, Blow JJ, Mehellou Y, Muqit MMK. 2018. The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1. ChemBioChem. 19(5):425-429. Available from: 10.1002/cbic.201700500

 

Crozier TWM, Tinti M, Wheeler RJ, Ly T, Ferguson MAJ, Lamond AI. 2018. Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei. Molecular & Cellular Proteomics. 17:1184-1195. Available from: 10.1074/mcp.RA118.000650

 

Dacks JB, Field MC. 2018. Evolutionary origins and specialisation of membrane transport. Current Opinion in Cell Biology. 53:70-76. Available from: 10.1016/j.ceb.2018.06.001

 

Fairlamb A, Horn D. 2018. Melarsoprol Resistance in African Trypanosomiasis. Trends in Parasitology. Available from: 10.1016/j.pt.2018.04.002

 

Fairlamb AH, Patterson S. 2018. Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis. Current Medicinal Chemistry. Available from: 10.2174/0929867325666180426164352

 

Herman EK, Ali M, Field MC, Dacks JB. 2018. Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins. Traffic. Available from: 10.1111/tra.12570

 

Holden JM, Koreny L, Obado S, Ratushny AV, Chen W-M, Bart J-M, Navarro M, Chait BT, Aitchison JD, Rout MP, Field MC. 2018. Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes. Molecular Biology of the Cell. 29(9). Available from: 10.1091/mbc.E17-06-0430

 

Jeacock L, Correia Faria J, Horn D. 2018. Codon usage bias controls mRNA and protein abundance in trypanosomatids. eLife. Available from: 10.7554/eLife.32496

 

Luise N, Wyatt P. 2018. Generation of Polar Semi-Saturated Bicyclic Pyrazoles for Fragment-Based Drug Discovery Campaigns. Chemistry: a European Journal. Available from: 10.1002/chem.201801313

 

MacLean L, Thomas J, Lewis MD, Cotillo I, Gray D, De Rycker M. 2018. Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery. PLoS Neglected Tropical Diseases.

 

Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, Soares De Melo C, Feng TS, Street LJ, Chibale K, Warner DF, Mizrahi V, Epemolu O, Scullion P, Ellis L, Riley J, Shishikura Y, Ferguson L, Osuna-Cabello M, Read KD, Green SR, Lamprecht DA, Steyn AJC, Ioerger TR, Sacchettini J, Rhee KY, Arora K, Barry CE, Wyatt PG, Boshoff HIM. 2018. 2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization. ACS Infectious Diseases. 4(6):954-969. Available from: 10.1021/acsinfecdis.7b00275

 

Pedron J, Boudot C, Hutter S, Bourgeade-Delmas S, Stigliani J-L, Sournia-Saquet A, Moreau A, Boutet-Robinet E, Paloque L, Mothes E, Laget M, Vendier L, Pratviel G, Wyllie S, Fairlamb A, Azas N, Courtioux B, Valentin A, Verhaeghe P. 2018. Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study. European Journal of Medicinal Chemistry. 155:135-152. Available from: 10.1016/j.ejmech.2018.06.001

 

Prati F, Zuccotto F, Fletcher D, Convery MA, Fernandez-Menendez R, Bates R, Encinas L, Zeng J, Chung C-W, De Dios Anton P, Mendoza-Losana A, Mackenzie C, Green SR, Huggett M, Barros D, Wyatt PG, Ray PC. 2018. Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA. ChemMedChem. 13(7):672-677. Available from: 10.1002/cmdc.201700774

 

Quintata J, Del Pino RC, Yamada K, Zhang N, Field MC. 2018. Adaptation and therapeutic exploration: a two edged tale of membrane space in trypanosomes. Genes 9, 368

 

Rico Vidal E, Jeacock L, Kovarova J, Horn D. 2018. Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes. Scientific Reports. 8:1-10. Available from: 1038/s41598-018-26303-w

 

Sienkiewicz N, Ong H, Fairlamb A. 2018. Characterisation of a putative glutamate 5‐kinase from Leishmania donovani. FEBS Journal. Available from: 10.1111/febs.14511

 

Steketee PC, Vincent IM, Achcar F, Giordani F, Kim DH, Creek DJ, Freund Y, Jacobs R, Rattigan K, Horn D, Field MC, MacLeod A, Barrett MP. 2018. Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases. 12(5). Available from: 10.1371/journal.pntd.0006450

 

Venkatesh D, Zhang N, Zoltner M, Canavate Del Pino R, Field MC. 2018. Evolution of protein trafficking in kinetoplastid parasites: complexity and pathogenesis. Traffic. Available from: 10.1111/tra.12601

 

Wall R, Moniz S, Thomas M, Norval S, Ko EJ, Marco M, Miles TJ, Gilbert I, Horn D, Fairlamb A, Wyllie S. 2018. Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals. Antimicrobial Agents and Chemotherapy. Available from: 10.1128/AAC.00235-18

 

Wyllie S, Thomas M, Patterson S, Crouch S, De Rycker M, Lowe R, Gresham S, Urbaniak MD, Otto TD, Stojanovski L, Simeons FRC, Manthri S, MacLean LM, Zuccotto F, Homeyer N, Pflaumer H, Boesche M, Sastry L, Connolly P, Albrecht S, Berriman M, Drewes G, Gray DW, Ghidelli-Disse S, Dixon S, Fiandor JM, Wyatt PG, Fergucaon MAJ, Fairlamb AH, Miles TJ, Read KD, Gilbert IH. 2018. Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis. Nature 560(7717): 192-197

 

Zhang N, Zoltner M, Leung K-F, Scullion P, Hutchinson S, Del Pino RC, Vincent IM, Zhang Y-K, Freund YR, Alley MRK, Jacobs RT, Read KD, Barrett MP, Horn D, Field MC. 2018. Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles. PLoS Pathogens. 14(2): e1006850. Available from: 10.1371/journal.ppat.1006850

 

Trunk, K., Peltier, J., Liu, Y., Dill, B.D., Walker, L., Gow, N.A.R., Stark, M.J.R., Quinn, J., Strahl, H., Trost, M. & Coulthurst, S.J. (2018) The Type VI secretion system deploys anti-fungal effectors against microbial competitors. Nature Microbiology, 3, 920–931.

Ostrowski, A., Cianfanelli, F.R., Porter, M., Mariano, G., Peltier, J., Wong, J., Swedlow, J.R., Trost, M. and Coulthurst, S.J. (2018) Killing with proficiency: integrated post-translational regulation of an offensive Type VI secretion system. PLoS Pathogens, 14, e1007230.

 

Dragoš A, Kiesewalter H, Martin M, Hsu CY, Hartmann R, Wechsler T, Eriksen C, Brix S, Drescher K, Stanley-Wall N, Kümmerli R, Kovács ÁT. 2018. Division of Labor during Biofilm Matrix Production. Current Biology. 28(12):1903-1913.e5. Available from: 10.1016/j.cub.2018.04.046

 

Erskine E, Morris RJ, Schor M, Earl C, Gillespie RMC, Bromley KM, Sukhodub T, Clark L, Fyfe P, Serpell LC, Stanley-Wall N, MacPhee CE. 2018. Formation of functional, non-amyloidogenic fibres by recombinant Bacillus subtilis TasA. Molecular Microbiology. Available from: doi.org/10.1111/mmi.13985

 

Jäger F, Kneuper H, Palmer T. 2018. EssC is a specificity determinant for Staphylococcus aureus type VII secretion. Microbiology. 164:816-820. Available from: 10.1099/mic.0.000650

Mariano G, Monlezun L, Coulthurst SJ. 2018. Dual Role for DsbA in Attacking and Targeted Bacterial Cells during Type VI Secretion System-Mediated Competition. Cell Reports. 22(3):774-785. Available from: 10.1016/j.celrep.2017.12.075

 

McOwat K, Stanley-Wall NR. 2018. Biofilm Building: A Simple Board Game to Reinforce Knowledge of Biofilm Formation. Journal of Microbiology & Biology Education. 19(1). Available from: 10.1128/jmbe.v19i1.1355

 

Owen RA, Fyfe PK, Lodge A, Biboy J, Vollmer W, Hunter WN, Sargent F. 2018. Structure and activity of ChiX, a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens. Biochemical Journal. 475(2):415-428. Available from: 10.1042/BCJ20170633

 

Roger M, Brown F, Gabrielli W, Sargent F. 2018. Efficient hydrogen‐dependent carbon dioxide reduction by Escherichia coli. Current Biology. 28(1):140-145e2. Available from: 10.1016/j.cub.2017.11.050

 

Trunk K, Peltier J, Liu Y-C, Dill BD, Walker L, Gow NAR, Stark M, Quinn J, Trost M, Coulthurst S. 2018. The Type VI secretion system deploys anti-fungal effectors against microbial competitors. Nature Microbiology.

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