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Publications

A selection of recent  publications from members of the Centre for Antimicrobial Resistance are shown below:

1.Habersetzer, J., Moore, K., Cherry, J., Buchanan, G., Stansfeld, P.J. and Palmer, T. (2017) Substrate-triggered position switching of TatA and TatB during Tat transport in Escherichia coliOpen Biology7:170091.

2.Huang, Q and Palmer, T. (2017) Signal peptide hydrophobicity modulates interaction with the twin-arginine translocase. mBio 8, pii: e00909-17. doi: 10.1128/mBio.00909-17.

3.Tooke, F.J., Babot, M., Chandra, G., Buchanan, G. and Palmer, T. (2017) A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways. eLife 6, pii: e26577. doi: 10.7554/eLife.26577

4.Lamont, C.M., Kelly, C.L., Pinske, C., Buchanan, G., Palmer, T. and Sargent F. (2017) Expanding the substrates for a bacterial hydrogenlyase reaction. MicrobiologyIn the press. doi: 10.1099/mic.0.000471

5. Palmer, T. (2017) Mycobacterial ESX secrets revealed. News and Views Article. Nature Microbiology 2, 17074. doi: 10.1038/nmicrobiol.2017.74

6. Huang, Q., Alcock, F., Kneuper, H., Deme, J.C., Rollauer, S.E. Lea, S.M., Berks, B.C. and Palmer, T. (2017) A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase. Proceedings of the National Academy of Sciences USA.114, E1958-E1967.

7. Unnikrishnan, M., Constantinidou, C., Palmer, T. and Pallen, M. (2017) The enigmatic Esx proteins: looking beyond mycobacteria. Trends in Microbiology 25, 192-204.

8. Sofia Arnaouteli$, Ana Sofia Ferreira$, Marieke Schor$, Ryan J. Morris, Keith M. Bromley, Jeanyoung K. Jo, Krista L. Cortez, Tetyana Sukhodub, Alan R. Prescott, Lars E. P. Dietrich, Cait E. MacPhee ^, Nicola R. Stanley-Wall ^ 2017 “Bifunctionality Of A Biofilm Matrix Protein Controlled By Redox State” Proceeding of the National Academy of Sciences USA 114 vol. 30 E6184-E6191 doi:10.1073/pnas.1707687114

$ These authors contributed equally; ^ Joint corresponding author

*Highlighted Nature Reviews Microbiology 15, pp 512–513 (2017) doi:10.1038/nrmicro.2017.91

 9.Jeacock L, Baker N, Wiedemar N, Mäser P and Horn D. (2017) Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity. *PLoS Pathogens. 13:e1006307
 
10. Field MC, Horn D, Fairlamb AH, Ferguson MAJ, Gray DW, Read KD, De Rycker M, Torrie LS, Wyatt PG, Wyllie S and Gilbert IH. (2017) Anti-trypanosomatid drug discovery: An ongoing challenge and a continuing need.Nature Reviews Microbiol. 15:217-231.

 

11. Chalmers, JD, Dicker, A, Woodhead, M & Madhava, H 2016, 'A systematic review of the burden of vaccine preventable pneumococcal disease in UK adults' BMC Pulmonary Medicine, vol 16, no. 1, 77. DOI: 10.1186/s12890-016-0242-0

12. Chalmers, JD, Reyes, LF, Aliberti, S & Restrepo, MI 2016, 'Empirical coverage of methicillin-resistant Staphylococcus aureus in community-acquired pneumonia: those who do not remember the past are doomed to repeat it' Clinical Infectious Diseases, vol 63, no. 8, pp. 1145-1146. DOI: 10.1093/cid/ciw464

13. Chalmers, JD 2016, 'Corticosteroids for community-acquired pneumonia: a critical view of the evidence' European Respiratory Journal, vol 48, no. 4, pp. 984-986. DOI: 10.1183/13993003.01329-2016

14.  Amalakuhan, B, Habib, SA, Mangat, M, Reyes, LF, Rodriguez, AH, Hinojosa, CA, Soni, NJ, Gilley, RP, Bustamante, CA, Anzueto, A, Levine, SM, Peters, JI, Aliberti, S, Sibila, O, Chalmers, JD, Torres, A, Waterer, GW, Martin-Loeches, I, Bordon, J, Blanquer, J, Sanz, F, Marcos, PJ, Rello, J, Ramirez, J, Solé-Violán, J, Luna, CM, Feldman, C, Witzenrath, M, Wunderink, RG, Stolz, D, Wiemken, TL, Shindo, Y, Dela Cruz, CS, Orihuela, CJ & Restrepo, MI 2016, 'Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis' Cytokine, vol 88, pp. 267-273. DOI: 10.1016/j.cyto.2016.08.028

15.  Wilcox, MH, Chalmers, JD, Nord, CE, Freeman, J & Bouza, E 2016, 'Role of cephalosporins in the era of Clostridium difficile infection' Journal of Antimicrobial Chemotherapy. DOI: 10.1093/jac/dkw385

16. Bellelli, G, Chalmers, JD, Sotgiu, G, Dore, S, McDonnell, MJ, Goeminne, PC, Dimakou, K, Skrbic, D, Lombi, A, Pane, F, Obradovic, D, Fardon, TC, Rutherford, RM, Pesci, A & Aliberti, S 2016, 'Characterization of bronchiectasis in the elderly' Respiratory Medicine, vol 119, pp. 13-19. DOI: 10.1016/j.rmed.2016.08.008

17. McDonnell MJ, Aliberti S, Goeminne PC, Restrepo MI, Pesci A, Dupont LJ, Fardon TC, Wilson R, Loebinger MR, Skrbic D, Obradovic D, De Soyza A, Ward C, Laffey JG, Rutherford R, Chalmers JD. Co-morbidities and the risk of mortality in patients with bronchiectasis. An international cohort study. Lancet Respiratory Medicine 2016 in press.

18. Cao, Z, Casabona, MG, Kneuper, H, Chalmers, JD & Palmer, T 2016, 'The Ess/Type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria' Nature Microbiology, vol 2, 16183. DOI: 10.1038/nmicrobiol.2016.183

19. Rodrigo-Troyano, A, Suarez-Cuartin, G, Peiró, M, Barril, S, Castillo, D, Sanchez-Reus, F, Plaza, V, Restrepo, MI, Chalmers, JD & Sibila, O 2016, 'Pseudomonas aeruginosa resistance patterns and clinical outcomes in hospitalized exacerbations of COPD' Respirology , vol 21, no. 7, pp. 1235-1242. DOI: 10.1111/resp.12825

20. Aliberti, S, Masefield, S, Polverino, E, De Soyza, A, Loebinger, MR, Menendez, R, Ringshausen, FC, Vendrell, M, Powell, P, Chalmers, JD &  on behalf of the EMBARC Study Group 2016, 'Research priorities in bronchiectasis: a consensus statement from the EMBARC Clinical Research Collaboration' European Respiratory Journal, vol 48, no. 3, pp. 632-647. DOI: 10.1183/13993003.01888-2015

21. Cillóniz, C, Torres, A, Niederman, M, van der Eerden, M, Chalmers, J, Welte, T & Blasi, F 2016, 'Community-acquired pneumonia related to intracellular pathogens' Intensive Care Medicine, vol 42, no. 9, pp. 1374-1386. DOI: 10.1007/s00134-016-4394-4

22. McDonnell, MJ, Alberti, S, Goeminne, PC, Dimakou, K, Davidson, J, Ward, C, LAffey, JG, Finch, S, Pesci, A, Dupont, LJ, Fardon, TC, Skrbic, D, Obradovic, D, Cowman, S, Loebinger, MR, Rutherford, RM, De Soyza, A & Chalmers, JD 2016, 'Multidimensional severity assessment in bronchiectasis: An analysis of 7 European cohorts.' Thorax. DOI: 10.1136/thoraxjnl-2016-208481

23. Suarez-Cuartin, G, Chalmers, JD & Sibila, O 2016, 'Diagnostic challenges of bronchiectasis' Respiratory Medicine, vol 116, pp. 70-77. DOI: 10.1016/j.rmed.2016.05.014

24. Chalmers, JD, Akram, AR, Singanayagam, A, Wilcox, MH & Hill, AT 2016, 'Risk factors for Clostridium difficile infection in hospitalized patients with community-acquired pneumonia' Journal of Infection, vol 73, no. 1, pp. 45-53. DOI: 10.1016/j.jinf.2016.04.008

25.  Chalmers, JD, Dicker, A, Woodhead, M & Madhava, H 2016, 'A systematic review of the burden of vaccine preventable pneumococcal disease in UK adults' BMC Pulmonary Medicine, vol 16, no. 1, 77. DOI: 10.1186/s12890-016-0242-0

26. Sibila, O, Garcia-Bellmunt, L, Giner, J, Rodrigo-Troyano, A, Suarez-Cuartin, G, Torrego, A, Castillo, D, Solanes, I, Mateus, EF, Vidal, S, Sanchez-Reus, F, Sala, E, Cosio, BG, Restrepo, MI, Anzueto, A, Chalmers, JD & Plaza, V 2016, 'Airway Mucin 2 is decreased in patients with severe chronic obstructive pulmonary disease with bacterial colonization' Annals of the American Thoracic Society, vol 13, no. 5, pp. 636-642. DOI: 10.1513/AnnalsATS.201512-797OC

27. Sotgiu, G, Dore, S, Chalmers, JD & Aliberti, S 2016, 'Clinical phenotypes in bronchiectasis: Right on track to develop precision medicine in respiratory diseases' International Journal of Tuberculosis and Lung Disease, vol 20, no. 5, pp. 709. DOI: 10.5588/ijtld.16.0194

28. Rae, N, Finch, S & Chalmers, JD 2016, 'Cardiovascular disease as a complication of community-acquired pneumonia' Current Opinion in Pulmonary Medicine, vol 22, no. 3, pp. 212-218. DOI: 10.1097/MCP.0000000000000261

29.  Aliberti, S, Lonni, S, Dore, S, McDonnell, MJ, Goeminne, PC, Dimakou, K, Fardon, T, Rutherford, R, Pesci, A, Restrepo, MI, Sotgiu, G & Chalmers, J 2016, 'Clinical phenotypes in adult patients with bronchiectasis' European Respiratory Journal, vol 47, no. 4, pp. 1113-1122. DOI: 10.1183/13993003.01899-2015

30.  Chalmers, JD, McDonnell, MJ, Rutherford, R, Davidson, J, Finch, S, Crichton, M, Dupont, L, Hill, AT, Fardon, TC, De Soyza, A, Aliberti, S & Goeminne, P 2016, 'The generalizability of bronchiectasis randomized controlled trials: a multicentre cohort study' Respiratory Medicine, vol 112, pp. 51-58. DOI: 10.1016/j.rmed.2016.01.016

31. Chalmers, JD, Aliberti, S, Polverino, E, Vendrell, M, Crichton, M, Loebinger, M, Dimakou, K, Clifton, I, van der Eerden, M, Rohde, G, Murris-Espin, M, Masefield, S, Gerada, E, Shteinberg, M, Ringshausen, F, Haworth, C, Boersma, W, Rademacher, J, Hill, AT, Aksamit, T, O'Donnell, A, Morgan, L, Milenkovic, B, Tramma, L, Neves, J, Menendez, R, Paggiaro, P, Botnaru, V, Skrgat, S, Wilson, R, Goeminne, P, De Soyza, A, Welte, T, Torres, A, Elborn, JS, Blasi, F & on behalf of EMBARC 2016, 'The EMBARC European Bronchiectasis Registry: protocol for an international observational study' ERJ Open Research, vol 2, no. 1, 00081-2015, pp. 1-9. DOI: 10.1183/23120541.00081-2015

32. Cianfanelli, FR, Alcoforado Diniz, J, Guo, M, De Cesare, V, Trost, M & Coulthurst, S 2016, 'VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System' PLoS Pathogens, vol 12, no. 6, e1005735. DOI: 10.1371/journal.ppat.1005735

33.  Cianfanelli, FR, Monlezun, L & Coulthurst, SJ 2016, 'Aim, Load, Fire: The Type VI Secretion System, a Bacterial Nanoweapon' Trends in Microbiology, vol 24, no. 1, pp. 51-62. DOI: 10.1016/j.tim.2015.10.005

34. Walker, H, Patton, A, Bayne, G, Marwick, C, Sneddon, J, Davey, P, Nathwani, D & Bell, S 2016, 'Reduction in post-operative acute kidney injury following a change in antibiotic prophylaxis policy for orthopaedic surgery: an observational study' Journal of Antimicrobial Chemotherapy, vol 71, no. 9, pp. 2598-2605. DOI: 10.1093/jac/dkw166

35. Davey, PG 2016, 'Structured antibiotic 'time-out' audits as recommended by the CDC reduce antibiotic use and costs' Evidence-Based Nursing, vol 19, no. 1, pp. 24. DOI: 10.1136/eb-2014-102046

36.Dewar, S, Sienkiewicz, N, Ong, HB, Wall, RJ, Horn, D & Fairlamb, AH 2016, 'The role of folate transport in antifolate drug action in Trypanosoma brucei' Journal of Biological Chemistry. DOI: 10.1074/jbc.M116.750422

37. Baragaña, B, Norcross, NR, Wilson, C, Porzelle, A, Hallyburton, I, Grimaldi, R, Osuna-Cabello, M, Norval, S, Riley, J, Stojanovski, L, Simeons, FRC, Wyatt, PG, Delves, MJ, Meister, S, Duffy, S, Avery, VM, Winzeler, EA, Sinden, RE, Wittlin, S, Frearson, JA, Gray, DW, Fairlamb, AH, Waterson, D, Campbell, SF, Willis, P, Read, KD & Gilbert, IH 2016, 'Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy' Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.6b00723

38. Roberts, AJ & Fairlamb, A 2016, 'The N-myristoylome of Trypanosoma cruzi' Scientific Reports, vol 6, 31078, pp. 1-11. DOI: 10.1038/srep31078

39. Norcross, NR, Baragana, B, Wilson, C, Hallyburton, I, Osuna-Cabello, M, Norval, S, Riley, J, Stojanovski, L, Simeons, FRC, Porzelle, A, Grimaldi, R, Wittlin, S, Duffy, S, Avery, VM, Meister, S, Sanz, L, Jimenez-Diaz, B, Angulo-Barturen, I, Ferrer, S, Santos Marinez, M, Javier Gamo, F, Frearson, JA, Gray, DW, Fairlamb, AH, Winzeler, EA, Waterson, D, Campbell, SF, Willis, P, Read, KD & Gilbert, IH 2016, 'Trisubstituted Pyrimidines as Efficacious and Fast-acting Antimalarials' Journal of Medicinal Chemistry, vol 59, no. 13, pp. 6101-6120. DOI: 10.1021/acs.jmedchem.6b00028

40. Fairlamb, AH, Gow, NAR, Matthews, KR & P. Waters, A 2016, 'Drug Resistance in Eukaryotic Microorganisms' Nature Microbiology, vol 1, no. 7, 16092. DOI: 10.1038/nmicrobiol.2016.92

41. Patterson, S, Wyllie, S, Norval, S, Stojanovski, L, Simeons, FRC, Auer, JL, Osuna-Cabello, M, Read, KD & Fairlamb, AH 2016, 'The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis' eLife, vol 5, e09744. DOI: 10.7554/eLife.09744

42. W. Gibson, M, Dewar, S, Ong, HB, Sienkiewicz, N & Fairlamb, A 2016, 'Trypanosoma brucei DHRF-TS revisited: characterisation of a bifunctional and highly unstable recombinant dihydrofolate reductase-thymidylate synthase' PLoS Neglected Tropical Diseases, vol 10, no. 5, e0004714, pp. 1-20. DOI: 10.1371/journal.pntd.0004714

43. Ballell, L, Strange, M, Cammack, N, Fairlamb, AH & Borysiewicz, L 2016, 'Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases' Nature Reviews Drug Discovery, vol 15, no. 4, 292. DOI: 10.1038/nrd.2016.51

44. Bruhn, DF, Wyllie, S, Rodríguez-Cortés, A, Carrillo, AK, Rakesh, Guy, RK, Fairlamb, AH & Lee, RE 2016, 'Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes' Journal of Antimicrobial Chemotherapy, vol 71, no. 4, dkv417, pp. 956-963. DOI: 10.1093/jac/dkv417

45. Fleming, JR, Sastry, L, Wall, SJ, Sullivan, L & Ferguson, MAJ 2016, 'Proteomic identification of immunodiagnostic antigens for Trypanosoma vivax infections in cattle and generation of a proof-of-concept lateral flow test diagnostic device' PLoS Neglected Tropical Diseases, vol 10, no. 9, e0004977. DOI: 10.1371/journal.pntd.0004977

46.  Larance, M, Kirkwood, KJ, Tinti, M, Brenes Murillo, A, Ferguson, M & Lamond, A 2016, 'Global membrane protein interactome analysis using in vivo crosslinking and MS-based protein correlation profiling' Molecular & Cellular Proteomics, vol 15, no. 7, pp. 2476-2490. DOI: 10.1074/mcp.O115.055467

47. Damerow, M, Graalfs, F, Guther, MLS, Mehlert, A, Izquierdo, L & Ferguson, MAJ 2016, 'A gene of the β3-glycosyltransferase family encodes N-acetylglucosaminyltransferase II function in Trypanosoma brucei' Journal of Biological Chemistry, vol 291, no. 26, pp. 13834-13845. DOI: 10.1074/jbc.M116.733246

48. Dacks, JB, Field, MC, Buick, R, Eme, L, Gribaldo, S, Roger, AJ, Brochier-Armanet, C & Devos, DP 2016, 'The changing view of eukaryogenesis - fossils, cells, lineages and how they all come together' Journal of Cell Science, vol 129, pp. 3695-3703. DOI: 10.1242/jcs.178566

49. Maishman, L, Obado, SO, Alsford, S, Bart, J, Chen, W-M, Ratushny, AV, Navarro, M, Horn, D, Aitchison, JD, Chait, BT, Rout, MP & Field, MC 2016, 'Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression' Nucleic Acids Research. DOI: 10.1093/nar/gkw751

50. Zoltner, M, Horn, D, de Koning, HP & Field, MC 2016, 'Exploiting the Achilles' heel of membrane trafficking in trypanosomes' Current Opinion in Microbiology, vol 34, pp. 97-103. DOI: 10.1016/j.mib.2016.08.005

51. Kalb, LC, Frederico, YCA, Boehm, C, Moreira, CMDN, Soares, MJ & Field, MC 2016, 'Conservation and divergence within the clathrin interactome of Trypanosoma cruzi' Scientific Reports, vol 6, 31212, pp. 1-12. DOI: 10.1038/srep31212

52.  Klinger, CM, Ramirez-Macias, I, Herman, EK, Turkewitz, AP, Field, MC & Dacks, JB 2016, 'Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology' Molecular and Biochemical Parasitology. DOI: 10.1016/j.molbiopara.2016.07.003

53. Koreny, L & Field, MC 2016, 'Ancient eukaryotic origin and evolutionary plasticity of nuclear lamina' Genome Biology and Evolution, vol 8, no. 10, pp. 2663-2671. DOI: 10.1093/gbe/evw087

54. Flegontov, P, Butenko, A, Firsov, S, Kraeva, N, Eliáš, M, Field, MC, Filatov, D, Flegontova, O, Gerasimov, ES, Hlaváčová, J, Ishemgulova, A, Jackson, AP, Kelly, S, Kostygov, AY, Logacheva, MD, Maslov, DA, Opperdoes, FR, O'Reilly, A, Sádlová, J, Ševčíková, T, Venkatesh, D, Vlček, Č, Volf, P, Votýpka, J, Záhonová, K, Yurchenko, V & Lukeš, J 2016, 'Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania' Scientific Reports, vol 6, 23704. DOI: 10.1038/srep23704

55.  Obado, SO, Brillantes, M, Uryu, K, Zhang, W, Ketaren, NE, Chait, BT, Field, MC & Rout, MP 2016, 'Interactome mapping reveals the evolutionary history of the nuclear pore complex' PLoS Biology, vol 14, no. 2, e1002365. DOI: 10.1371/journal.pbio.1002365

56.  Heider, MR, Gu, M, Duffy, CM, Mirza, AM, Marcotte, LL, Walls, AC, Farrall, N, Hakhverdyan, Z, Field, MC, Rout, MP, Frost, A & Munson, M 2016, 'Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex' Nature Structural & Molecular Biology, vol 23, no. 1, pp. 59-66. DOI: 10.1038/nsmb.3146

57. Herrera, LJ, Brand, S, Santos, A, Nohara, LL, Harrison, J, Norcross, NR, Thompson, S, Smith, V, Lema, C, Varela-Ramirez, A, Gilbert, IH, Almeida, IC & Maldonado, RA 2016, 'Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi' PLoS Neglected Tropical Diseases, vol 10, no. 4, e0004540. DOI: 10.1371/journal.pntd.0004540

58. Gage, ZO, Vasou, A, Gray, DW, Randall, RE & Adamson, CS 2016, 'Identification of novel inhibitors of the type I interferon induction pathway using cell-based high-throughput screening' Journal of Biomolecular Screening, vol 21, no. 9, pp. 978-988. DOI: 10.1177/1087057116656314

59. De Rycker, M, Thomas, J, Riley, J, Brough, SJ, Miles, TJ & Gray, DW 2016, 'Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade' PLoS Neglected Tropical Diseases, vol 10, no. 4, e0004584. DOI: 10.1371/journal.pntd.0004584

60.  Moynié, L, Hope, AG, Finzel, K, Schmidberger, J, Leckie, SM, Schneider, G, Burkart, MD, Smith, AD, Gray, DW & Naismith, JH 2016, 'A substrate mimic allows high-throughput assay of the FabA protein and consequently the identification of a novel inhibitor of Pseudomonas aeruginosa FabA' Journal of Molecular Biology, vol 428, no. 1, pp. 108-120. DOI: 10.1016/j.jmb.2015.10.027

61.  Hutchinson, S, Glover, L & Horn, D 2016, 'High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes' BMC Genomics, vol 17, 806. DOI: 10.1186/s12864-016-3154-8

62.  Graf, FE, Ludin, P, Arquint, C, Schmidt, RS, Schaub, N, Kunz Renggli, C, Munday, JC, Krezdorn, J, Baker, N, Horn, D, Balmer, O, Caccone, A, de Koning, HP & Mäser, P 2016, 'Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense' Cellular and Molecular Life Sciences, vol 73, no. 17, pp. 3387-3400. DOI: 10.1007/s00018-016-2173-6

63. Glover, L, Hutchinson, S, Alsford, S & Horn, D 2016, 'VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes' Proceedings of the National Academy of Sciences of the United States of America, vol 113, no. 26, pp. 7225-7230. DOI: 10.1073/pnas.1600344113

64.  Duraisingh, MT & Horn, D 2016, 'Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa' Cell Host & Microbe, vol 19, no. 5, pp. 629-640. DOI: 10.1016/j.chom.2016.04.020

64. Horn, D 2016, 'How Antiparasitic Drugs Work-And Sometimes Stop Working!' PLoS Pathogens, vol 12, no. 5, pp. e1005430. DOI: 10.1371/journal.ppat.1005430

66. Song, J, Baker, N, Rothert, M, Henke, B, Jeacock, L, Horn, D & Beitz, E 2016, 'Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2' PLoS Pathogens, vol 12, no. 2, e1005436. DOI: 10.1371/journal.ppat.1005436

67. Stewardson, AJ, Allignol, A, Beyersmann, J, Graves, N, Schumacher, M, Meyer, R, Tacconelli, E, De Angelis, G, Farina, C, Pezzoli, F, Bertrand, X, Gbaguidi-Haore, H, Edgeworth, J, Tosas, O, Martinez, JA, Ayala-Blanco, MP, Pan, A, Zoncada, A, Marwick, CA, Nathwani, D, Seifert, H, Hos, N, Hagel, S, Pletz, M, Harbarth, S & TIMBER Study Group 2016, 'The health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study' Eurosurveillance, vol 21, no. 33, Article 2, pp. 1-12. DOI: 10.2807/1560-7917.ES.2016.21.33.30319

68.   Francis, NA, Ridd, MJ, Thomas-Jones, E, Shepherd, V, Butler, CC, Hood, K, Huang, C, Addison, K, Longo, M, Marwick, C, Wootton, M, Howe, R, Roberts, A, Haq, MI-U, Madhok, V & Sullivan, F 2016, 'A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study' Health Technology Assessment, vol 20, no. 19, pp. 1-84. DOI: 10.3310/hta20190

69. Bonnici-Mallia, M, Kanodia, AK, Rae, N & Marwick, C 2016, 'Herpes simplex encephalitis: unusual imaging appearances' BMJ Case Reports, vol 2016. DOI: 10.1136/bcr-2016-214993

70.  Rae, N, Jarchow-MacDonald, A, Nathwani, D & Marwick, CA 2016, 'MRSA: treating people with infection' BMJ Clinical Evidence.

71. Burton, LA, Price, R, Barr, KE, McAuley, SM, Allen, JB, Clinton, AM, Phillips, G, Marwick, CA, McMurdo, MET & Witham, MD 2016, 'Hospital-acquired pneumonia incidence and diagnosis in older patients' Age and Ageing, vol 45, no. 1, pp. 171-174. DOI: 10.1093/ageing/afv168

72.  Brink, AJ, Messina, AP, Feldman, C, Richards, GA, Becker, PJ, Goff, DA, Bauer, KA, Nathwani, D, van den Bergh, D & on behalf of the Netcare Antimicrobial Stewardship Study Alliance 2016, 'Antimicrobial stewardship across 47 South African hospitals: an implementation study' Lancet Infectious Diseases, vol 16, no. 9, pp. 1017-1025. DOI: 10.1016/S1473-3099(16)30012-3

73. Nathwani, D, Dryden, M & Garau, J 2016, 'Early clinical assessment of response to treatment of skin and soft-tissue infections: How can it help clinicians? Perspectives from Europe' International Journal of Antimicrobial Agents, vol 48, no. 2, pp. 127-136. DOI: 10.1016/j.ijantimicag.2016.04.023

74. Dickstein, Y, Nir-Paz, R, Pulcini, C, Cookson, B, Beović, B, Tacconelli, E, Nathwani, D, Vatcheva-Dobrevska, R, Rodríguez-Baño, J, Hell, M, Saenz, H, Leibovici, L & Paul, M 2016, 'Staffing for infectious diseases, clinical microbiology and infection control in hospitals in 2015: results of an ESCMID-member survey ' Clinical Microbiology and Infection. DOI: 10.1016/j.cmi.2016.06.014

75.  Munnoch, JT, Widdick, D, Chandra, G, Sutcliffe, IC, Palmer, T & Hutchings, MI 2016, 'Cosmid based mutagenesis causes genetic instability in Streptomyces coelicolor, as shown by targeting of the lipoprotein signal peptidase gene' Scientific Reports, vol 6, 29495. DOI: 10.1038/srep29495

76. Zoltner, M, Ng, WMAV, Money, JJ, Fyfe, PK, Kneuper, H, Palmer, T & Hunter, WN 2016, 'EssC: domain structures inform on the elusive translocation channels in the Type VII secretion system.' Biochemical Journal, vol 473, no. 13, pp. 1941-1952. DOI: 10.1042/BCJ20160257

77. Warne, B, Harkins, CP, Harris, SR, Vatsiou, A, Stanley-Wall, N, Parkhill, J, Peacock, SJ, Palmer, T & Holden, MTG 2016, 'The Ess/Type VII secretion system of Staphylococcus aureus shows unexpected genetic diversity' BMC Genomics, vol 17, 222. DOI: 10.1186/s12864-016-2426-7

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